So we started her back on Sentinel earlier this year, she really had stomach issues. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. As with any topical, of course keep an eye out for skin irritation. This is so thorough and helpful! My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). To help with this, the product can be applied in more than one line between the neck and shoulder blades. I have never even heard of the latter and do not believe they exist in Canada. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. The drawback of Advantage is that it does not offer any protection against ticks. It was winter. Thank you for this thorough and thoughtful work, Emily! However, some of the combination flea+heartworm preventive products (those containing the ingredient, "spinosad") should be used cautiously in dogs that are MDR1 mutant because of a risk of serious drug-drug interactions. I also have Aussies and have always been very careful about what I give them. Thanks. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. I just had my vet mention the mdr1 gene today in passing. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Remember she is fixed. The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 mutation. Specifically, does it contain any form of -mectin (i.e. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. Hi. I have been told that Advocate is safe for him at the recommended dose. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. Please keep me updated if you think of it! These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Dogs with the mutation will react to those drugs. However, as with any chemical compounds, caution is advised even with products deemed to be safe. What do you think about Frontline Gold? I doubt these would be cheaper than fipronil but it's worth checking. I plan to switch him over to Trifexis also. For my Aussie mix, Ive had success using Advantix II. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Liver disease. Simparica (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Appreciated!!! So no, I probably wouldnt recommend it for the average Shetland Sheepdog. From the standpoint of MDR1 dogs, it is safe. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. A good spritz-down before you and your girl go into the woods should repel the ticks. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. It probably is the safest as it is aimed only at preventing heartworm. Best of luck with your girl! If you'd like to know for sure if your dog carries this gene, there are genetic tests available. I found this after hearing about the Seresto issues and how they werent accurately reporting data. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. I do remember her cowering and rubbing her back against her crate after we administered anything topical! This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). However, it did make my Collies too itchy. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! This year she has a very high degree of irritation when applied (I had to wash it off). Hi Debbie! Thank you so much for writing this article!!! However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Theyre so fun and crazy at that age. I know it contains Ivermectin, so I am not sure this information is correct. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Some of these alternatives include: . I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies. I follow this advice, since Im a safe-is-better-than-sorry person. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. My two cats were father and son so probably carried the same gene. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Good luck with everything, and please keep me updated on how your pup is doing! But of course, do talk to your vet and see what they know. Doses of ivermectin used for treating mange or ear mites can be dangerous for dogs with the mutation and are especially dangerous when combined with spinosad (seen in some flea medications like Comfortis or Trifexis), even for normal dogs. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Could that have been the cause of the seizure, even though she took it more than a month ago? Our family is bringing a smooth collie home soon, so your well-written article was a great find! I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. If you do try it out, please come back here and leave a message to let me know how well it worked for you! On the down side, it does not cover any ticks. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. . Another one that still seems to be working good is afoxolaner (Nexgard). mg) Indications Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. She has always had a sensitive stomach, but as she gets older, it gets worse. It treats both heart and intestinal parasites. Thanks for reply. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. My Aussie/Pyrenees mix has had no issues with it, for instance. Best of luck! Giardia can be passed to and cause diarrhea in humans. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Fleas this summer in my part of CA are particularly bad. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Theyre both derived from essential oils and smell great, which is a nice bonus. You might want to look at the information on Nexgard. The rx I currently use on my dogs is serolaner (Simparica). That way if a tick does make it past the essential oil barrier and bite, itll die anyway. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. My plan is to adopt a senior Border to go with my lazy Roughs. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. . While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. But the drug works just like Bravecto and Nexgard it destroys flea and tick nervous systems. Happy to help! In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. ? If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . Additionally, it can also be given to cats and even pregnant or nursing animals. . Thank you for bringing this to my attention! Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. Thanks! Yes, Simparica is a good flea treatment for dogs. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Im sincerely grateful!! When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. (One such knockoff, Pet Armor Plus, is even available at Walmart.). What Can Cause Seizures in Dogs? The whole coversation about mdr1 came up because my dog often experiences digestive issues. Mary. Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and selamectin; and the anti-diarrheal Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Frontline Gold and Frontline Shield. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. Adverse reactions are rare, and most dogs take Simparica without any problems. Im glad you found it helpful. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Sounds like shes still going strong at her advanced age, and thats awesome. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. Good luck with the puppies, and I hope they get healthy soon. Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. Ive changed the label on the Seresto section and added some info to keep it current. Is hartz ultraguard ear mite treatment for dogs safe? Infected dogs should be treated with an adulticide to remove adult heartworms. Other medications that should be used with caution and at reduced doses include sedatives like acepromazine and butorphanol, anti-cancer medications and more. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. After logging in you can close it and return to this page. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. Fleas were treated with effifax, active ingredient fipronil. Is Frontline Plus still safe? Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. Thank you, and hello to Nola and Otis! I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Thank you for all your research and article!! 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